Cate Speake

The paper identifies a type I IFN-driven monocyte dysregulation and a MAS-associated CD8+ T cell population in macrophage activation syndrome using bulk and single-cell RNA sequencing.

This study identifies soluble LAG-3 (sLAG-3) as an early biomarker of T cell activation in type 1 diabetes, detectable before islet autoantibody development and associated with beta-cell stress and high-risk HLA genotypes.

This study compares the effects of two IL-6 inhibitors on serum extracellular vesicles using proteomics, finding distinct protein pathway alterations.

This study shows UC-associated autoantibodies to αvβ6 inhibit mucosal TGFβ activation, disrupt epithelial homeostasis, and increase susceptibility to intestinal inflammation.

This study uses multi-omic profiling to analyze immune cell dynamics in healthy adults over time, finding age-related transcriptional changes in T cells and impaired memory B cell responses in older adults.

The paper identifies immune alterations preceding rheumatoid arthritis onset and provides tools for dataset exploration.

The paper identifies shared transcriptional and cell communication signatures in RA patients and at-risk individuals, showing how multiple pathogenic mechanisms contribute to disease initiation and progression.

The paper identifies biomarkers and genetic variants associated with COVID-19 linked secondary hemophagocytic lymphohistiocytosis (sHLH) and links them to immune system defects.

The paper identifies shifts in isoform usage in Tregs associated with Type 1 Diabetes by comparing gene expression between cases and controls.