Jigang Yin

A rapid sporozoite viability assay identifies anti-Cryptosporidium parvum leads and targetable enzymatic activities in the invasive stage

This paper develops a rapid host cell-free assay to screen anti-Cryptosporidium compounds, identifies five effective inhibitors, and links them to targetable enzymatic activities in sporozoites.

A comprehensive proteome and the first phosphoproteome reveal extensive phosphorylation of carbohydrate metabolism in Cryptosporidium parvum sporozoites

This paper presents a comprehensive proteome and phosphoproteome of Cryptosporidium parvum sporozoites, revealing limited phosphorylation of core metabolic enzymes and emphasizing phosphorylation in regulatory and structural processes.

A suture-specific oocyst wall protein COWP4 is essential for excystation and infectivity, while COWP6 links wall architecture to host interaction in Cryptosporidium parvum

This paper identifies COWP4 and COWP6 as distinct oocyst wall proteins in Cryptosporidium parvum, showing COWP4 is essential for suture formation and infectivity while COWP6 links wall structure to host interaction.

The protein translation initiation machinery is targetable for developing fast-killing therapeutics against the zoonotic Cryptosporidium parvum

This paper identifies CpeIF4A as a novel drug target for anti-cryptosporidial therapeutics and shows that Roc-A inhibits parasite growth in vitro and in vivo.