Impaired KCC2 phosphorylation leads to neuronal network dysfunction and neurodevelopmental pathogenesis.
Lucie Isoline Pisella, Jean‐Luc Gaïarsa, Diabé Diabira, Jinwei Zhang, Ilgam Khalilov, Jingjing Duan, Kristopher Thomas Kahle, Igor Medina
This study shows that impaired KCC2 phosphorylation in mice leads to neuronal network dysfunction and neurodevelopmental issues, with some effects reversible by bumetanide treatment.
Science Signaling · Oct 15, 2019Peer-reviewedNeuroscience