Diabé Diabira

Leptin antagonism improves Rett syndrome phenotype in symptomatic Mecp2-deficient mice.

This study shows that reducing leptin signaling alleviates Rett syndrome symptoms in Mecp2-deficient mice by improving neurological and physiological functions.

Oxytocin administration in neonates shapes the hippocampal circuitry and restores social behavior in a mouse model of autism.

This study shows that oxytocin administration in neonatal Magel2-deficient mice restores hippocampal circuitry and social memory, suggesting therapeutic potential for autism.

Impaired KCC2 phosphorylation leads to neuronal network dysfunction and neurodevelopmental pathogenesis.

This study shows that impaired KCC2 phosphorylation in mice leads to neuronal network dysfunction and neurodevelopmental issues, with some effects reversible by bumetanide treatment.