Igor Medina

This study investigates how pro- and mature BDNF regulate chloride homeostasis via KCC2 in rat neurons, showing their distinct roles in inhibitory neurotransmission and developmental behavior.

This study shows that oxytocin administration in neonatal Magel2-deficient mice restores hippocampal circuitry and social memory, suggesting therapeutic potential for autism.

This study shows that Smo signaling regulates the shift of GABA polarity in rat somatosensory cortex by controlling KCC2 stability and chloride homeostasis.

This study shows that impaired KCC2 phosphorylation in mice leads to neuronal network dysfunction and neurodevelopmental issues, with some effects reversible by bumetanide treatment.