Author

Lesley D. O’Brien

Virginia Commonwealth UniversityORCID 0000-0002-5877-3976Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Ajay NadigiD· 1 shared Ally A. NicolellaiD· 1 shared Aron H. LichtmaniD· 1 shared Bryan J. SongiD· 1 shared Joshua Z. LeviniD· 1 shared Kira A. Perzel MandelliD· 1 shared Kira S. BrenneriD· 1 shared Min Jee KwoniD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperNeuroscience

Ajay NadigORCID

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1 paper

Recent·Most cited

Meta-analysis of the brain transcriptomes of multiple genetic mouse models of schizophrenia highlights dysregulation in striatum and thalamus

Kira A. Perzel Mandell, Sean Simmons, Ajay Nadig, Zohreh Farsi, Wei-Chao Huang, Sameer Aryal, Min Jee Kwon, Bryan J. Song, Kira S. Brenner, Nate Shepard, Ally A. Nicolella, Lesley D. O’Brien, Aron H. Lichtman, Joshua Z. Levin, Morgan Sheng

This study performs a meta-analysis of brain transcriptomes from genetic mouse models of schizophrenia, identifying dysregulation in striatum and thalamus with distinct patterns in different models.

Translational Psychiatry · Sep 29, 2025Peer-reviewedNeuroscience