Bryan J. Song

The paper compares microglia-targeted AAVs, finding that capsid choice affects in vitro efficiency but not in vivo transduction when using specific promoters.

This study investigates Akap11 mutant mice to explore the neurobiological effects of AKAP11 loss, finding increased PKA activity and transcriptomic changes linked to schizophrenia and bipolar disorder.

This study performs a meta-analysis of brain transcriptomes from genetic mouse models of schizophrenia, identifying dysregulation in striatum and thalamus with distinct patterns in different models.

This study identifies AKAP11's role in regulating lipid metabolism and neuronal support in astrocytes, linking its dysfunction to schizophrenia and bipolar disorder risk.

This study uses multi-omics analyses of Sp4 mutant mice to reveal synapse disruption and age- and region-specific neuronal and glial changes linked to schizophrenia and bipolar disorder.

This study shows that SRRM2 haploinsufficiency in mice causes synaptic, splicing, and myelination defects linked to schizophrenia-like behaviors and gene expression changes.

This study identifies brain region-specific changes and dopamine dysregulation in Grin2a mutant mice, supporting schizophrenia hypotheses and highlighting their utility as a genetic model.

This study examines EEG abnormalities in Grin2a and Akap11 mutant mice, finding similarities with schizophrenia patients, suggesting these mutants as models for the disorder.

The paper describes a model in flies that uses daily neural circuit rewiring to predict environmental light changes based on time-of-day.