Author

Kira S. Brenner

Broad InstituteORCID 0000-0001-6638-5300Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:differential expression· 3 Organism:mouse· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Research Focus:benchmarking· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Ally A. NicolellaiD· 3 shared Bryan J. SongiD· 3 shared Morgan ShengiD· 3 shared Nate ShepardiD· 3 shared Sameer AryaliD· 3 shared Zohreh FarsiiD· 3 shared Hasmik KeshishianiD· 2 shared Joshua Z. LeviniD· 2 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersNeuroscience

Ally A. NicolellaORCID

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3 papers

Recent·Most cited

NeuroscienceTranslational PsychiatryPeer-reviewedSep 29, 2025

Meta-analysis of the brain transcriptomes of multiple genetic mouse models of schizophrenia highlights dysregulation in striatum and thalamus

Kira A. Perzel Mandell, Sean Simmons, Ajay Nadig…·Morgan Sheng

This study performs a meta-analysis of brain transcriptomes from genetic mouse models of schizophrenia, identifying dysregulation in striatum and thalamus with distinct patterns in different models.

4 citations

mousebulk RNA-seq

𝕏 PostBluesky

NeurosciencebioRxivPreprintOct 10, 2024

SRRM2 haploinsufficiency drives SynGAP-γ reduction, Agap3 mis-splicing, and oligodendrocyte deficits in a mouse model of schizophrenia

Sameer Aryal, Chuhan Geng, Margaret A. Yin…·Morgan Sheng

This study shows that SRRM2 haploinsufficiency in mice causes synaptic, splicing, and myelination defects linked to schizophrenia-like behaviors and gene expression changes.

5 citations

mousebulk RNA-seq

𝕏 PostBluesky

NeurosciencebioRxivPreprintNov 15, 2022

Brain region-specific changes in neurons and glia and dysregulation of dopamine signaling in Grin2a mutant mice

Zohreh Farsi, Ally A. Nicolella, Sean Simmons…·Morgan Sheng

This study identifies brain region-specific changes and dopamine dysregulation in Grin2a mutant mice, supporting schizophrenia hypotheses and highlighting their utility as a genetic model.

3 citations

mouseproteomics

𝕏 PostBluesky