Esther Borges Florsheim

Cholera toxin remodels intestinal immunity and suppresses systemic metabolism

This study shows that cholera toxin alone rapidly reorganizes intestinal immunity, epithelial, metabolic, and microbial environments while suppressing whole-body metabolism in mice.

Sennoside A differentially regulates mast cell activation and attenuates gut allergic inflammation

This study shows sennoside A modulates mast cell activation differently under resting and allergic conditions, reducing allergic inflammation in a mouse model of food allergy.

Repeated shrimp allergen exposure drives 5-lipoxygenase-dependent avoidance and selective gut-brain activation

This study shows that repeated shrimp allergen exposure leads to 5-lipoxygenase-dependent avoidance and specific gut-brain activation in mice.

Systemic endotoxemia induces integrated sickness physiology in female BALB/c mice

This study shows that systemic LPS induces a coordinated sickness state in female BALB/c mice, linking peripheral inflammation with metabolic, redox, neuronal, and behavioral changes.

Maternal obesity induces developmental programming of Intestinal stem cells through an IL-17A/PPAR immune-epithelial axis

This study shows maternal obesity programs intestinal stem cells through an IL-17A/PPAR axis, increasing cancer risk in offspring.

Systemic Dosing of Virus-derived Serpin Improves Survival and Immunothrombotic Damage in Murine Colitis

This study shows that PEGSerp-1, a virus-derived serpin, improves survival and reduces immunothrombotic damage in a mouse colitis model.