Author

Dominic R. Saiz

Arizona State UniversityORCID 0000-0002-9878-7635Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:CITE-seq· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

Benjamin B. BartelleiD· 3 shared Fiona FarnsworthiD· 3 shared Gourab LahiriiD· 3 shared Miyeko ManaiD· 3 shared Thomas Hartley McDermottiD· 3 shared Yesenia Barrera MillaniD· 3 shared Eric Uher· 2 shared Karla F MulleniD· 2 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCell Biology

Benjamin B. BartelleORCID

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3 papers

Recent·Most cited

Maternal obesity induces developmental programming of Intestinal stem cells through an IL-17A/PPAR immune-epithelial axis

Gourab Lahiri, Yesenia Barrera Millan, Swathi Sankar, Karla F Mullen, Thomas Hartley McDermott, Dominic R. Saiz, Fiona Farnsworth, Matthew Torel, Madeline Blatt, Ana Cristina Roginski, Abhigyan Shukla, Esther Borges Florsheim, Benjamin B. Bartelle, Khashayarsha Khazaie, Fotini Gounari, Miyeko Mana

This study shows maternal obesity programs intestinal stem cells through an IL-17A/PPAR axis, increasing cancer risk in offspring.

bioRxiv · Mar 16, 2026 · PreprintCell Biology

O-GlcNAcylation regulates PPAR-driven metabolic programming in intestinal stem cells

Thomas Hartley McDermott, Dominic R. Saiz, Yesenia Barrera Millan, Ngoc Anh Ho, Matthew Torel, Eric Uher, Caleb Impraim Aboagye, Fiona Farnsworth, Gourab Lahiri, Venkataramana Thiriveedi, Jinhua CHI, Haiwei Gu, Charlie Fehl, Benjamin B. Bartelle, Miyeko Mana

This study shows that O-GlcNAcylation regulates PPAR-driven metabolic programming in intestinal stem cells by linking dietary metabolism to transcriptional control.

bioRxiv · Mar 16, 2026 · PreprintCell Biology

Diet-induced chromatin states influence intestinal stem cell memory

Dominic R. Saiz, Yesenia Barrera Millan, Thomas Hartley McDermott, Gabriella Cerna, Swathi Sankar, Fiona Farnsworth, Eric Uher, Gourab Lahiri, Kelly Lintecum, Karla F Mullen, Benjamin B. Bartelle, Miyeko Mana

The paper shows diet-induced chromatin changes in intestinal stem cells persist even after diet normalization and influence stem cell behavior.

bioRxiv · Feb 20, 2026 · PreprintCell Biology