Differentiation drives widespread rewiring of the neural stem cell chaperone network
Willianne I. M. Vonk, T. Kelly Rainbolt, Patrick Dolan, Ashley E. Webb, Anne Brunet, Judith Frydman
This study shows that neural stem cell differentiation rewires the chaperone network, reducing TRiC/CCT and increasing sHSPs, which shifts proteostasis strategy and may contribute to neurodegenerative disease susceptibility.
Molecular Cell · Apr 1, 2020Peer-reviewedMolecular Biology