T. Kelly Rainbolt

The paper curates a list of 838 high-confidence components of the autophagy-lysosome pathway as part of a comprehensive effort to define the human proteostasis network.

The paper defines and annotates 959 genes comprising the human proteostasis network, focusing on translation, protein folding, and organelle-specific systems.

This study shows that neural stem cell differentiation rewires the chaperone network, reducing TRiC/CCT and increasing sHSPs, which shifts proteostasis strategy and may contribute to neurodegenerative disease susceptibility.