Author

Lillian M. Guenther

St. Jude Children's Research HospitalORCID 0000-0002-5906-7504Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Gang WuiD· 2 shared Monika Wierdl· 2 shared A Herman· 1 shared A Robichaud· 1 shared Adam David DurbiniD· 1 shared Alejandro Sweet-CorderoiD· 1 shared Alise K. BlakeiD· 1 shared Anang A. ShelatiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

Gang WuORCID

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintJul 20, 2026

Chemokine-Dependent Natural Killer Cells Prevent Pulmonary Metastasis in a Newly Established Mouse Osteosarcoma Model

Jifeng Yang, Frédérique Zindy, Shaela Fields…·Chunliang Li

This study identifies CCL2 as a chemokine that limits osteosarcoma metastasis via NK cell signaling in a mouse model.

DOI 10.64898/2026.07.19.738728

mousebulk RNA-seq

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Cancer BiologybioRxivPreprintMay 28, 2026

Tabular foundation model predicts alternative lengthening of telomeres (ALT) and identifies SMARCAL1 as a target in ALT-driven cancers

Declan Bennett, Monika Wierdl, S Chakraborty…·Lillian M. Guenther

The paper develops ALTitude, a machine learning model to predict ALT status from whole genome sequencing data, identifies SMARCAL1 as a therapeutic target in ALT-driven cancers.

1 citation

humanwhole-genome sequencing

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Genetic & Genomic MedicineJournal of Clinical OncologyPeer-reviewedOct 9, 2025

Germline variation in DNA damage repair genes in children with cancer: Unveiling SMARCAL1 as novel osteosarcoma predisposition gene

Ninad Oak, Wenan Chen, Alise K. Blake…·Richa Sharma

The paper identifies SMARCAL1 as a novel predisposition gene for osteosarcoma by analyzing germline variants in DNA damage repair genes across childhood cancer cases.

10 citationstop 3%

humanwhole-exome sequencing

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