Author

Simon Heeke

The University of Texas MD Anderson Cancer CenterORCID 0000-0002-5916-534XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Carl Michael GayiD· 2 shared Catherine Allison StewartiD· 2 shared Jing WangiD· 2 shared John Victor HeymachiD· 2 shared Kavya RamkumariD· 2 shared Lauren A. ByersiD· 2 shared Lixia DiaoiD· 2 shared Pedro RochaiD· 2 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Carl Michael GayORCID

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2 papers

Recent·Most cited

Cancer BiologyJournal of Thoracic OncologyPeer-reviewedApr 20, 2026

YAP1 defines an emergent, plastic population of relapsed small cell lung cancer

Catherine Allison Stewart, Kavya Ramkumar, Runsheng Wang…·Carl Michael Gay

This study identifies YAP1-positive cells in relapsed SCLC that exhibit drug tolerance and transition from SCLC to LCNEC-like features, losing some targets but gaining others.

8 citationstop 1%

humanbulk RNA-seq

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Cancer BiologyMolecular CancerPeer-reviewedMar 20, 2025

DNA damage response signatures are associated with frontline chemotherapy response and routes of tumor evolution in extensive stage small cell lung cancer

Benjamin B. Morris, Simon Heeke, Yuanxin Xi…·Lauren A. Byers

This study identifies three distinct DDR phenotypes in SCLC associated with chemotherapy response and tumor evolution.

9 citations

humanbulk RNA-seq

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