Yuanxin Xi

This study identifies YAP1-positive cells in relapsed SCLC that exhibit drug tolerance and transition from SCLC to LCNEC-like features, losing some targets but gaining others.

This study clarifies that NOTCH1 acts as a tumor suppressor in head and neck cancer, reducing cancer stem cells and improving prognosis, despite conflicting prior reports.

This study identifies three distinct DDR phenotypes in SCLC associated with chemotherapy response and tumor evolution.

This study identifies PI3K-mTOR pathway inhibition as a strategy to overcome acquired resistance to KRASG12C inhibitors in NSCLC by targeting 4E-BP1.

This study shows that SMARCA4 mutations in lung cancer disrupt enhancer landscapes and innate immune gene expression, leading to immunotherapy resistance.