Humanized Caffeine-Inducible Systems for Controlling Cellular Functions
Leo Scheller, Maddalena Elia, Lucia Bonati, Chungwon Kang, Pablo Gaínza, Yash Garodia, Pranitha Deshpande, Joseph H. Schmidt, Tom Enbar, Sandrine Georgeon, Li Tang, Bruno E. Correia
The paper develops caffeine-inducible systems for controlling gene expression in human cells using humanized protein components and demonstrates their use in inducible gene expression in T-cells.
bioRxiv · Jun 13, 2025 · PreprintSynthetic Biology