Maddalena Elia

This study designs metamorphic proteins that switch between multiple conformations and shows how mutations can shift their conformational equilibrium.

The paper develops caffeine-inducible systems for controlling gene expression in human cells using humanized protein components and demonstrates their use in inducible gene expression in T-cells.

This paper designs proteins that target neosurfaces from protein-ligand complexes using a deep learning approach, validated experimentally against three drug-bound protein complexes.