Céline Delpech

This study shows that axon guidance defects prevent functional recovery in CNS regeneration and that suppressing Slit/Robo signaling enables axons to reinnervate the SCN, leading to behavioral recovery.

The paper uses quantitative proteomic analysis to identify guidance molecules and associated factors in the adult visual system, revealing their potential role in axon guidance during CNS regeneration.

The paper proposes using adult retina explants as an ex vivo model to study axon regeneration in the mature CNS, offering advantages over in vitro and in vivo approaches.