Alain Chédotal

This study evaluates precision-cut liver slices as an ex vivo model for studying HBV/HDV co-infection and testing antiviral agents.

The paper develops a synthetic Fab yeast display library integrated with machine learning to discover antibodies against cell surface antigens, yielding hundreds of validated antibodies and a public dataset.

This paper creates an integrated multimodal atlas of the female reproductive system across the lifespan, identifying cell types and linking them to gynaecological pathologies.

Human Developmental Cell Atlas integrates ~4.6 million cells/nuclei from 4-22 post-conception weeks into 454 refined cell types and maps 114 spatial niches across 6PCW whole-embryo sections.

The paper refines a human heart atlas using multi-modal data from the first trimester, identifying novel cell types and spatial features in cardiac development.

This paper creates a human embryonic limb cell atlas using single-cell and spatial transcriptomics, identifying novel cell populations and developmental patterns.

This study shows that axon guidance defects prevent functional recovery in CNS regeneration and that suppressing Slit/Robo signaling enables axons to reinnervate the SCN, leading to behavioral recovery.

The paper maps the single-cell transcriptome of human fetal gonads to define somatic cell lineage specification during development.

The paper maps the multi-organ functions of the human yolk sac during early development, revealing its roles in hematopoiesis, nutrition, and oxygen regulation.

This study shows that GSK3 signaling regulates the genesis of displaced ganglion cells in the retina, with loss of GSK3 leading to increased numbers of these cells and altered axon projections.

This study shows that DCC and NTN1 regulate astroglial development and interhemispheric fissure remodeling, essential for corpus callosum and hippocampal commissure formation.

This study shows that loss of floor plate Netrin-1 disrupts corticospinal tract midline crossing in mice, causing mirror movements similar to human congenital conditions.

This study identifies Phox2a as a marker for anterolateral system neurons in mice and humans, showing their role in nociceptive signal relay and conservation across species.

This study shows that cerebellar dopamine D2 receptors in Purkinje cells regulate social novelty preference in mice without affecting motor functions.

The paper uses single-cell transcriptomics to map hematopoiesis in human fetal liver, identifying cell differentiation trajectories and shifts in hematopoietic composition during development.