Cell BiologybioRxivPreprint
IBD risk locus rs1077773 is a pharmacogenomic eQTL for aryl hydrocarbon receptor activity and modulates immune cell function.
Ashley C. King, Kristen M. Seiler, Kerry A. Swanson…·David M. Alvarado
This paper identifies rs1077773 as a pharmacogenomic eQTL for AHR activity, showing it enhances transcriptional activity in organoids and reduces inflammatory cytokine production in macrophages.
DOI 10.1101/2025.09.26.678301