Matthew A. Ciorba

This study develops mouse models of perianal fistulizing Crohn's disease and identifies IFN-gamma signaling as a therapeutic target.

This study shows that locally produced complement factor B in the gut reduces colitis, highlighting its role in mucosal immunity.

This paper identifies rs1077773 as a pharmacogenomic eQTL for AHR activity, showing it enhances transcriptional activity in organoids and reduces inflammatory cytokine production in macrophages.