Kristen M. Seiler

This paper identifies rs1077773 as a pharmacogenomic eQTL for AHR activity, showing it enhances transcriptional activity in organoids and reduces inflammatory cytokine production in macrophages.

The paper uses single-cell RNA sequencing to show that mice adapt to small bowel resection by reprogramming distal intestinal enterocytes to a proximal identity, driven by retinoid metabolism and Creb3l3.