BioinformaticsbioRxivPreprint
From Proteome Mining to Structural Validation: Phosphopyruvate Hydratase as a Structurally Tractable Drug Target in Kinetoplastid Parasites
Luis Daniel Goyzueta-Mamani, Haruna Luz Barazorda-Ccahuana, Michelle G. Ng…·Miguel Á. Chávez‐Fumagalli
The paper identifies phosphopyruvate hydratase (PPH) as a drug target in kinetoplastid parasites through proteome mining, structural modeling, and experimental validation, and identifies hinokinin as a promising antiparasitic compound.