Author

David Stephen Shulman

Harvard UniversityORCID 0000-0002-5994-2604Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Approach:statistical model· 2 Assay:whole-genome sequencing· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Brian D. CromptoniD· 3 shared Kelly S. KlegaiD· 2 shared Mohammad TanhaemamiiD· 2 shared Advaita Chakraborty· 1 shared Alejandra E. Aguilar-QuinteroiD· 1 shared Amr Salem· 1 shared Anne-Florence BlandiniD· 1 shared Brigit McDannell· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersCancer Biology

Brian D. CromptonORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintSep 18, 2026

Clustered structural variant hotspots enable oncogenic addiction and plasticity in osteosarcoma

Shreya Raman, Thorsten Kaltenbacher, David Merrell…·Riaz Gillani

The paper identifies clustered structural variant hotspots in osteosarcoma, linking them to oncogenic addiction and plasticity through transcriptional changes and clinical detectability.

DOI 10.64898/2026.09.14.751472

humanwhole-genome sequencing

Cancer BiologyTranslational OncologyPeer-reviewedJun 18, 2026

A novel combination of CDK4/6 and PI3K inhibitors exhibits highly synergistic activity and translational potential in Ewing sarcoma.

Helen F. Gloege, Maria Ana Isabel C. De Los Santos, Advaita Chakraborty…·Brian D. Crompton

This paper identifies a synergistic combination of CDK4/6 and PI3K inhibitors that shows strong anti-Ewing sarcoma activity and improved survival in a xenograft model.

1 citation

humanbulk RNA-seq

GenomicsbioRxivPreprintJan 15, 2026

Multi-omic Longitudinal Analysis of Canine Osteosarcoma Identifies Inter-Patient Heterogeneity and Immune Enrichment in Metastatic Lesions

Christopher R. Husted, Kerstin Seidel, Tanya T. Karagiannis…·Heather L. Gardner

This study analyzes multi-omic data from canine osteosarcoma to identify inter-patient heterogeneity and immune enrichment in metastatic lesions.

2 citations

whole-genome sequencingscRNA-seq