Author

Kelly S. Klega

Broad InstituteORCID 0000-0002-3424-2003Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Brian D. CromptoniD· 3 shared David Stephen ShulmaniD· 2 shared Mohammad TanhaemamiiD· 2 shared Advaita Chakraborty· 1 shared Alejandra E. Aguilar-QuinteroiD· 1 shared Alessandro MeddaiD· 1 shared Amr Salem· 1 shared Ananthan SadagopaniD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCancer Biology

Brian D. CromptonORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Clustered structural variant hotspots enable oncogenic addiction and plasticity in osteosarcoma

Shreya Raman, Thorsten Kaltenbacher, David Merrell, Kavya Prasad, Yutaro Tanaka, Jakob Weiss, Emily Iannetta, Byron Butaney, Emily Jorswieck, Amr Salem, Lorena Lazo de la Vega, Evelina Ceca, Julia MW Wong, Suzanne J. Forrest, Kelly S. Klega, , Riaz Gillani

The paper identifies clustered structural variant hotspots in osteosarcoma, linking them to oncogenic addiction and plasticity through transcriptional changes and clinical detectability.

bioRxiv · Sep 18, 2026 · PreprintCancer Biology

A novel combination of CDK4/6 and PI3K inhibitors exhibits highly synergistic activity and translational potential in Ewing sarcoma.

Helen F. Gloege, Maria Ana Isabel C. De Los Santos, Advaita Chakraborty, Madhav Chadha, Alejandra E. Aguilar-Quintero, Min Shen, Caleb Heaslip, Sarah Finstuen-Magro, Brigit McDannell, Mohammad Tanhaemami, Stephanie C. Meyer, Kelly S. Klega, Yaqin Zhang, David Stephen Shulman, Steven G. DuBois, , Brian D. Crompton

This paper identifies a synergistic combination of CDK4/6 and PI3K inhibitors that shows strong anti-Ewing sarcoma activity and improved survival in a xenograft model.

Translational Oncology · Jun 18, 2026Peer-reviewedCancer Biology

Detection and monitoring of translocation renal cell carcinoma via plasma cell-free epigenomic profiling

Simon Garinet, Karl Semaan, Jiao Li, Ananthan Sadagopan, John Canniff, Noa Phillips, Kelly S. Klega, Medha Panday, Hunter Savignano, Matthew P. Davidsohn, Kevin Lyons, Alessandro Medda, Prateek Khanna, Mingkee Achom, Prathyusha Konda, , Srinivas Raghavan Viswanathan

This paper detects and monitors translocation renal cell carcinoma (tRCC) using plasma cell-free epigenomic profiling, achieving high accuracy in distinguishing tRCC from other cancers and healthy controls.

Journal of Clinical Investigation · Feb 1, 2026Peer-reviewedGenomics