Advaita Chakraborty

A novel combination of CDK4/6 and PI3K inhibitors exhibits highly synergistic activity and translational potential in Ewing sarcoma.

This paper identifies a synergistic combination of CDK4/6 and PI3K inhibitors that shows strong anti-Ewing sarcoma activity and improved survival in a xenograft model.

Hypusinated and unhypusinated isoforms of eIF5A exert distinct effects in models of pancreas development and function

This study investigates the distinct roles of hypusinated and unhypusinated eIF5A isoforms in pancreas development and function using zebrafish and mouse models.

12-Lipoxygenase inhibition improves glucose homeostasis and obesity-associated inflammation in human gene replacement mice

This study shows that inhibiting 12-LOX improves glucose homeostasis and reduces obesity-related inflammation in human gene replacement mice.

12-Lipoxygenase inhibition delays onset of autoimmune diabetes in human gene replacement mice

This study shows that inhibiting 12-LOX with VLX-1005 delays autoimmune diabetes onset in human gene replacement mice by altering inflammatory pathways and immune cell infiltration.

Co-occupancy analysis reveals novel transcriptional synergies for axon growth

The paper identifies novel transcription factor synergies that enhance axon growth by analyzing co-occupancy patterns and validating them through experimental screens and animal models.

KLF6 and STAT3 co-occupy regulatory DNA and functionally synergize to promote axon growth in CNS neurons

This study shows KLF6 promotes axon growth in CNS neurons by co-occupying regulatory DNA with STAT3, leading to synergistic gene expression changes.