Alistair McGregor

This study evaluates a bivalent GPCMV vaccine and finds it provides limited cross-strain protection due to impaired gB antibody response and evasion of pp65 cell-mediated immunity.

This study identifies redundant entry receptors for GPCMV in guinea pig cells, showing that PDGFRA and NRP2 mediate direct and endocytic entry respectively, with additional receptor ThBD contributing to infection in epithelial cells.

This study shows that a combined vaccine encoding trimeric gB and IE1 proteins provides complete cross-strain protection against congenital cytomegalovirus in guinea pigs, surpassing protection from either antigen alone.

This study identifies key receptors for GPCMV entry in guinea pig cells and shows that knocking out these receptors blocks infection while leaving HSV-1 unaffected.