Characterization of MEK1/2 Degraders Uncovers a Kinase-Independent Role for MEK1/2 in the Stabilization and Maturation of CRAF
Jason S. Wasserman, Alison Kurimchak, Carlos Herrera-Montávez, Glenn A. R. Doyle, Brandon D. Fox, Ishadi K. M. Kodikara, Xiaoping Philip Hu, Jianping Hu, Jian Jun Jin, James S. Duncan
The paper identifies a kinase-independent role of MEK1/2 in stabilizing and maturing CRAF through direct binding, independent of catalytic activity.
bioRxiv · Mar 11, 2025 · PreprintCancer Biology