Author

James S. Duncan

Fox Chase Cancer CenterORCID 0000-0002-1276-2745Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:protein design· 1

Frequent Co-Authors

Alison KurimchakiD· 4 shared Jason S. WassermaniD· 3 shared Ishadi K. M. Kodikara· 2 shared Aasiya Remtulla· 1 shared Alexandre Chuyen· 1 shared Alicia Canuel· 1 shared Arminja Nadine KettenbachiD· 1 shared Brandon D. Fox· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersCell Biology

Alison KurimchakORCID

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Author profile →

4 papers

Recent·Most cited

MRCKα represses GEF-H1 mediated RhoA activation to promote ovarian cancer spheroid growth and invasion.

Aasiya Remtulla, Alison Kurimchak, Alicia Canuel, Ishadi K. M. Kodikara, Jason S. Wasserman, Alexandre Chuyen, Danielle Olding, Rajesh Gupta, Nikolina Radulovich, James S. Duncan, Michael F. Olson

This study identifies MRCKα as a repressor of GEF-H1-mediated RhoA activation, promoting ovarian cancer spheroid growth and invasion.

bioRxiv · Feb 9, 2026 · PreprintCell Biology

Rac1 Selectively Binds a Specific Lamellipodin Isoform via a Noncanonical Helical Interface

Tong Gao, Pingfeng Zhang, Alison Kurimchak, James S. Duncan, Jinhua Wu

The paper shows that the short Lpd isoform specifically binds Rac1 via a noncanonical helical interface, revealing a novel isoform-dependent GTPase-effector interaction.

Journal of Biological Chemistry · Dec 6, 2025Peer-reviewedBiochemistry

Characterization of MEK1/2 Degraders Uncovers a Kinase-Independent Role for MEK1/2 in the Stabilization and Maturation of CRAF

Jason S. Wasserman, Alison Kurimchak, Carlos Herrera-Montávez, Glenn A. R. Doyle, Brandon D. Fox, Ishadi K. M. Kodikara, Xiaoping Philip Hu, Jianping Hu, Jian Jun Jin, James S. Duncan

The paper identifies a kinase-independent role of MEK1/2 in stabilizing and maturing CRAF through direct binding, independent of catalytic activity.

bioRxiv · Mar 11, 2025 · PreprintCancer Biology

FAM122A ensures cell cycle interphase progression and checkpoint control as a SLiM-dependent substrate-competitive inhibitor to the B55/PP2A phosphatase

Jason S. Wasserman, Bulat Faezov, Kishan R. Patel, Alison Kurimchak, Seren M. Palacio, Holly A. Fowle, Brennan C McEwan, Qifang Xu, Ziran Zhao, Lauren E. Cressey, Neil Johnson, James S. Duncan, Arminja Nadine Kettenbach, Roland L. Dunbrack, Xavier Graña

This paper identifies FAM122A as a SLiM-dependent inhibitor of B55/PP2A that competes with substrates to regulate cell cycle progression and checkpoint control.

bioRxiv · Mar 6, 2023 · PreprintMolecular Biology