MicrobiologyProceedings of the National Academy of SciencesPeer-reviewed
Structure-guided design, synthesis, and characterization of C22- and C32-modified FK520 analogs with enhanced activity against human pathogenic fungi
Patrick A. Dome, Pyeonghwa Jeong, Gibeom Nam…·Jiyong Hong
This paper designs and synthesizes C22- and C32-modified FK520 analogs with enhanced antifungal activity and reduced immunosuppression by leveraging structural insights from fungal and human CaN-FKBP12 complexes.
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