Hongjun Jang

This study shows that inhibiting REV1, a TLS polymerase, increases trinucleotide repeat instability in human cells, suggesting REV1 protects against TNR mutagenesis.

This paper designs and synthesizes C22- and C32-modified FK520 analogs with enhanced antifungal activity and reduced immunosuppression by leveraging structural insights from fungal and human CaN-FKBP12 complexes.

The paper shows that AR inhibition in prostate cancer causes DNA replication stress, which can be exploited by combining with a TLS inhibitor to enhance treatment efficacy.