This study identifies RBM39 as a noncovalent target of the KRAS G12C inhibitor divarasib and reveals an RBM39-INSR signaling axis that influences cytotoxicity.

bioRxiv · Aug 20, 2026 · PreprintPharmacology & Toxicology

Identification of 4,5,6,7-Tetrabromo-1H-benzotriazole (TBB) as a Small Molecule MESH1 Inhibitor that Suppresses Ferroptosis

Alexander A. Mestre, Yunju Oh, Jianli Wu, Denise Dunn, Yasaman Setayeshpour, Ssu-Yu Chen, Chao‐Chieh Lin, C. Skyler Cochrane, Pyeonghwa Jeong, Gibeom Nam, Chloe Markey, Daniel Reker, Scott Floyd, Jiyong Hong, Pei Zhou, Jen‐Tsan Chi

This paper identifies TBB as a small molecule inhibitor of MESH1 that suppresses ferroptosis in vitro and reduces neuronal death in an Alzheimer's disease model.

bioRxiv · Feb 20, 2026 · PreprintBiochemistry

Structure-guided design, synthesis, and characterization of C22- and C32-modified FK520 analogs with enhanced activity against human pathogenic fungi

Patrick A. Dome, Pyeonghwa Jeong, Gibeom Nam, Hongjun Jang, Angela Rivera, Anna Floyd Averette, Eunchong Park, Tzu-Chieh Liao, Maria Ciofani, Jianli Wu, Jen‐Tsan Chi, Ronald A. Venters, Hyunju Park, William J. Steinbach, Praveen R. Juvvadi, , Jiyong Hong

This paper designs and synthesizes C22- and C32-modified FK520 analogs with enhanced antifungal activity and reduced immunosuppression by leveraging structural insights from fungal and human CaN-FKBP12 complexes.

Proceedings of the National Academy of Sciences · Dec 31, 2024Peer-reviewedMicrobiology