Pyeonghwa Jeong

The paper develops a DART platform to selectively modulate GABAA receptor subunits using neurosteroids, identifying C11-linked compounds that enhance GABA currents in 4/{delta}-containing receptors.

This paper identifies TBB as a small molecule inhibitor of MESH1 that suppresses ferroptosis in vitro and reduces neuronal death in an Alzheimer's disease model.

The paper introduces a one-step method to create cell-impermeable fluorescent HaloTag substrates for live-cell imaging and super-resolution microscopy.

This paper designs and synthesizes C22- and C32-modified FK520 analogs with enhanced antifungal activity and reduced immunosuppression by leveraging structural insights from fungal and human CaN-FKBP12 complexes.