Jen‐Tsan Chi

This study identifies ferroptosis as a vulnerability in stiff tumors mediated by YAP-SKP2 signaling, showing that stiff tumors are susceptible to ferroptosis induction despite chemotherapy resistance.

This study identifies RBM39 as a noncovalent target of the KRAS G12C inhibitor divarasib and reveals an RBM39-INSR signaling axis that influences cytotoxicity.

This study shows ascites protects ovarian cancer cells from ferroptosis and promotes peritoneal metastasis by modulating lipid metabolism and iron homeostasis.

This paper identifies TBB as a small molecule inhibitor of MESH1 that suppresses ferroptosis in vitro and reduces neuronal death in an Alzheimer's disease model.

This study shows that KLHL3 and WNK kinases are regulated by O-GlcNAcylation, affecting osmolarity control and ferroptosis, with implications for blood pressure and neuronal health.

This study shows that ATM inhibition with AZD1390 reduces ferroptosis and neuronal death in ischemic stroke models.

This paper designs and synthesizes C22- and C32-modified FK520 analogs with enhanced antifungal activity and reduced immunosuppression by leveraging structural insights from fungal and human CaN-FKBP12 complexes.

This paper shows NINJ1 protects cancer cells from ferroptosis by interacting with xCT antiporter and modulating CoA and GSH levels.

This study identifies CoA-mediated post-translational modification of TXNRD2 as a novel mechanism regulating the mitochondrial thioredoxin system to protect against ferroptosis.