Author
University of BristolORCID 0000-0002-6024-4950Unclaimed ORCID profile · follow to get notified of new preprints
Mutual co-authors in cluster
5 papers
Recent·Most cited
Andrew R. Elmore, Aimee Hanson, Genevieve M Leyden…·Gibran Hemani
The paper introduces GPMap, a resource that maps genetic associations across traits and molecular measurements to identify pleiotropy and improve disease mechanism understanding.
Genevieve M Leyden, Panagiota Pagoni, Grace Marion Power…·Eleanor C. M. Sanderson
This paper evaluates age-varying genetic effects on BMI and blood pressure traits using UK Biobank data, finding trait-dependent interactions that influence cardiovascular outcomes.
Maria K. Sobczyk, Tom G. Richardson, Genevieve M Leyden, Tom R. Gaunt
This paper compares two Mendelian Randomization approaches to assess pathway-specific effects of blood pressure and BMI on cardiovascular traits, finding distinct contributions from different Mendelian disease categories.
Tom G. Richardson, Genevieve M Leyden, Qin Wang…·Michael Vaclav Holmes
This study uses Mendelian randomization to compare the effects of lipid-modifying drug targets on CAD risk and blood metabolome traits across 115,082 UK Biobank participants.
Genevieve M Leyden, Tom R. Gaunt, Tom G. Richardson
This paper uses factorial Mendelian randomization to identify 20 genes that could reduce cardiovascular disease risk when combined with statin therapy, with PRKCE showing potential benefits without adverse effects.