Bhanu P. Jena

This paper demonstrates that porosome reconstitution with apigenin reverses Alzheimer's features in human brain organoids by repairing synaptic and metabolic defects.

The paper uses AI to uncover how beta-amyloid disrupts neuronal secretory machinery and develops a dual-target therapeutic framework to repair synaptic and mitochondrial defects in Alzheimer's.

The paper demonstrates that peptide and small molecule inhibitors of ATAD3A oligomers can restore neuronal viability and reduce oxidative stress in Alzheimer's disease neurons.

This paper demonstrates that introducing functional porosomes with wild-type CFTR into CF cells restores mucin secretion more effectively than TRIKAFTA.