Xin Qi

The paper uses AI to uncover how beta-amyloid disrupts neuronal secretory machinery and develops a dual-target therapeutic framework to repair synaptic and mitochondrial defects in Alzheimer's.

This study develops a decoy peptide, CS2, that disrupts the ClpP-αSynuclein interaction, reducing neuropathology in Parkinson's disease models.

The paper demonstrates that peptide and small molecule inhibitors of ATAD3A oligomers can restore neuronal viability and reduce oxidative stress in Alzheimer's disease neurons.

This study analyzes phosphoproteome dysregulation in 5XFAD mice, identifying sex-specific and temporal patterns, novel biomarkers, and a key kinase pathway involved in Alzheimer's disease progression.

The paper shows that cells use an adaptive pausing response to survive severe stress by pausing translation and limiting ATP use, followed by recovery through ISR signaling.