Author

Daniel Chavarría

Vanderbilt UniversityORCID 0000-0002-6042-2825Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Assay:imaging· 1 Organism:mouse· 1

Frequent Co-Authors

Ethan S. LippmanniD· 3 shared Alexander P LigockiiD· 2 shared Andrew KjariD· 2 shared Matthew SchragiD· 2 shared A. Scott McCalliD· 1 shared Alena Shostak· 1 shared Alexis K. YatesiD· 1 shared Angela Lee JeffersoniD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersBioengineering

Ethan S. LippmannORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

BioengineeringAdvanced Healthcare MaterialsPeer-reviewedJan 12, 2026

Anatomically and Physiologically Accurate Engineered Neurovascular Unit and Blood-Brain Barrier Model Using Microvessels Isolated from Postmortem Human Brain Tissue

Brian J. O’Grady, A. Scott McCall, Samuel Cullison…·Ethan S. Lippmann

The paper develops a human brain vasculature-on-a-chip model using microvessels from postmortem tissue, demonstrating anatomical and physiological features of the blood-brain barrier.

2 citations

humanimaging

𝕏 PostBluesky

NeuroscienceFluids and Barriers of the CNSPeer-reviewedJul 15, 2025

Substrate stiffness and shear stress collectively regulate the inflammatory phenotype in cultured human brain microvascular endothelial cells

Alexis K. Yates, Heather Murray, Andrew Kjar…·Ethan S. Lippmann

This study shows that intermediate substrate stiffness promotes inflammation in human brain microvascular endothelial cells, which is reduced by fluid shear stress.

10 citationstop 4%

humanbulk RNA-seq

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BioengineeringbioRxivPreprintMar 12, 2025

Amyloid-β-regulated gene circuits for programmable Alzheimer's disease therapy

Madeline R. Spetz, Hyosung Kim, Alexander P Ligocki…·Jonathan M. Brunger

This paper develops A{beta}-sensitive synthetic Notch receptors for engineered astrocytes to target amyloid-{beta} in Alzheimer's disease and modulate the neurodegenerative niche.

3 citations

mouseproteomics

𝕏 PostBluesky