Andrew Kjar

This study identifies the Gata4-Loxl2b axis as critical for scar-free spinal cord regeneration in zebrafish by regulating ECM remodeling and glial function.

The paper develops a human brain vasculature-on-a-chip model using microvessels from postmortem tissue, demonstrating anatomical and physiological features of the blood-brain barrier.

This paper demonstrates that an intravenous lipid-siRNA conjugate can deliver gene silencing to brain barriers without affecting parenchymal tissue.

This study shows that intermediate substrate stiffness promotes inflammation in human brain microvascular endothelial cells, which is reduced by fluid shear stress.

This study develops a lipid-siRNA conjugate that uses perivascular transport to achieve long-lasting gene knockdown in the CNS without toxicity.

The paper develops ADAR-mediated fluorescent RNA sensors to specifically track C3+ reactive astrocyte subpopulations in iPSC-derived models.

This study shows that IQGAP2 regulates immune cell entry into the CNS by modulating BBB function through adhesion receptors and antigen-processing machinery.