Alena Shostak

Lipid-siRNA conjugate accesses a perivascular transport mechanism and achieves widespread and durable knockdown in the central nervous system

This study develops a lipid-siRNA conjugate that uses perivascular transport to achieve long-lasting gene knockdown in the CNS without toxicity.

Amyloid-β-regulated gene circuits for programmable Alzheimer's disease therapy

This paper develops A{beta}-sensitive synthetic Notch receptors for engineered astrocytes to target amyloid-{beta} in Alzheimer's disease and modulate the neurodegenerative niche.

IQGAP2 regulates blood-brain barrier immune dynamics

This study shows that IQGAP2 regulates immune cell entry into the CNS by modulating BBB function through adhesion receptors and antigen-processing machinery.

Phospholipase D3 regulates lysosomal morphology, biogenesis, and function in neurons.

This study shows PLD3 regulates lysosomal morphology, biogenesis, and function in neurons by affecting protein abundance, subcellular location, and clearance of aggregated proteins.

Arteriolar degeneration and stiffness in cerebral amyloid angiopathy are linked to β-amyloid deposition and lysyl oxidase.

This study links β-amyloid deposition and lysyl oxidase to arteriolar degeneration and stiffness in cerebral amyloid angiopathy using post-mortem human brain tissue analysis.

Reactive astrocytes transduce blood-brain barrier dysfunction through a TNFα-STAT3 signaling axis and secretion of alpha 1-antichymotrypsin

PLD3 is a neuronal lysosomal phospholipase D associated with β-amyloid plaques and cognitive function in Alzheimer’s disease