Ethan S. Lippmann

This study identifies the Gata4-Loxl2b axis as critical for scar-free spinal cord regeneration in zebrafish by regulating ECM remodeling and glial function.

This study evaluates how aging affects the distribution and gene silencing activity of lipid-siRNA conjugates in the cerebrospinal fluid of mice.

This study investigates how MICOS disruption affects mitochondrial structure and function in neurons vulnerable to Alzheimer's disease, linking these changes to early mitochondrial dysfunction and neuronal vulnerability.

The paper develops a human brain vasculature-on-a-chip model using microvessels from postmortem tissue, demonstrating anatomical and physiological features of the blood-brain barrier.

This paper demonstrates that an intravenous lipid-siRNA conjugate can deliver gene silencing to brain barriers without affecting parenchymal tissue.

This study shows that intermediate substrate stiffness promotes inflammation in human brain microvascular endothelial cells, which is reduced by fluid shear stress.

This study develops a lipid-siRNA conjugate that uses perivascular transport to achieve long-lasting gene knockdown in the CNS without toxicity.

The paper develops ADAR-mediated fluorescent RNA sensors to specifically track C3+ reactive astrocyte subpopulations in iPSC-derived models.

This paper develops A{beta}-sensitive synthetic Notch receptors for engineered astrocytes to target amyloid-{beta} in Alzheimer's disease and modulate the neurodegenerative niche.

This study shows that IQGAP2 regulates immune cell entry into the CNS by modulating BBB function through adhesion receptors and antigen-processing machinery.

This study links β-amyloid deposition and lysyl oxidase to arteriolar degeneration and stiffness in cerebral amyloid angiopathy using post-mortem human brain tissue analysis.

This study shows that amyloid-β exposure in astrocytes increases apo-transferrin levels, which enhances iron transport from endothelial cells at the blood-brain barrier, contributing to early iron accumulation in Alzheimer's disease.

The paper describes a method to engineer RNA-based biosensors for mammalian cells using random sequence libraries, demonstrating a biosensor for L-dopa detection.

The paper identifies 17β-estradiol and CAT-1 as regulators of leptin transport across an iPSC-derived blood-brain barrier model.

This study shows that different basal media compositions significantly affect BBB properties in human iPSC-derived BMEC-like cells, influencing passive and active transport and signaling pathways.

The paper uses CRISPRi screens and single-cell transcriptomics in human astrocytes to identify regulators of inflammatory reactive states and their relevance in disease.

This paper uses machine learning to predict small molecule teratogenicity from structural and bioactivity data, identifying chemical features associated with teratogenic risk.