Richard J McDowell

This paper introduces optoDRD1, a photoswitchable optoGPCR that reversibly controls Gs and arrestin signaling using distinct wavelengths of light.

The paper identifies and characterizes far-red-sensitive opsins in mantis shrimp eyes, revealing their spectral tuning mechanisms and photoreversibility.

This study identifies a key amino acid in human OPN5 responsible for UV sensitivity and develops visible light-sensitive variants through site-directed mutagenesis.

The paper develops methods to quantify ambient light for mammals using species-specific photoreceptor-based measurements, showing improved physiological prediction compared to lux.

This paper demonstrates that Lamplight, a bistable opsin, can be used for switchable and scalable optogenetic inhibition of neurons in mice.