Author

Polina Isaikina

Paul Scherrer InstituteORCID 0000-0003-4466-7715Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

Andreea PantiruiD· 1 shared Anne SpangiD· 1 shared Deborah WalteriD· 1 shared Gebhard F. X. SchertleriD· 1 shared Hiruttika RavimohaniD· 1 shared Ivana M. PetroviciD· 1 shared Layara Akemi AbikoiD· 1 shared Richard J McDowelliD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperSynthetic Biology

Andreea PantiruORCID

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2 papers

Recent·Most cited

Synthetic BiologybioRxivPreprintJul 1, 2026

Photoswitchable optoGPCRs for reversible control of Gs and arrestin signalling

Deborah Walter, Richard J McDowell, Polina Isaikina…·Gebhard F. X. Schertler

This paper introduces optoDRD1, a photoswitchable optoGPCR that reversibly controls Gs and arrestin signaling using distinct wavelengths of light.

DOI 10.64898/2026.07.01.735182

experimental assaydrug response / drug discovery

𝕏 PostBluesky

BiochemistrybioRxivNov 4, 2024

A high-resolution analysis of arrestin2 interactions responsible for CCR5 endocytosis

Ivana M. Petrovic, Samit Desai, Polina Isaikina…·Stephan Grzesiek

This study identifies how arrestin2 interacts with clathrin and AP2 during CCR5 endocytosis, showing that AP2 binding depends on arrestin2 activation and phosphorylation levels.

1 citation

humanproteomics

𝕏 PostBluesky