Jun Hyoung Park

This paper identifies AADAT as a metabolic immune checkpoint in TNBC that promotes immune evasion by regulating malate and CoQ10, and shows that malate supplementation can reverse immunotherapy resistance.

This study identifies ophiobolin A's mechanism of action against EMT-positive breast cancer cells, showing mitochondrial and metabolic disruption with antioxidant countermechanisms.

This study shows that loss of MECR causes elevated ceramide levels and impaired iron metabolism, linking mitochondrial fatty acid synthesis to neurodegeneration.

The paper models the coupling of gene regulation and metabolic pathways in cancer, showing AMPK and HIF-1 activity correlates with metabolic pathway activities in tumor samples.