Benny Abraham Kaipparettu

This paper shows that Tamoxifen and Doxorubicin together target the ER beta-mutant p53-p73 axis in TNBC, enhancing cell death through apoptosis and ferroptosis.

This study identifies TAK1 as a key regulator of oncogenic signaling and differentiation blockade in rhabdomyosarcoma, showing its role in promoting proliferation and inhibiting myogenic differentiation.

This paper identifies AADAT as a metabolic immune checkpoint in TNBC that promotes immune evasion by regulating malate and CoQ10, and shows that malate supplementation can reverse immunotherapy resistance.

This paper develops a computational model of cancer metabolism integrating catabolic and anabolic pathways, identifying four metabolic phenotypes and their association with patient survival.

This study identifies ophiobolin A's mechanism of action against EMT-positive breast cancer cells, showing mitochondrial and metabolic disruption with antioxidant countermechanisms.

This study shows that loss of MECR causes elevated ceramide levels and impaired iron metabolism, linking mitochondrial fatty acid synthesis to neurodegeneration.

The paper models the coupling of gene regulation and metabolic pathways in cancer, showing AMPK and HIF-1 activity correlates with metabolic pathway activities in tumor samples.