Ming Hu

ArcFISH identifies 3D genome features from multiplexed DNA FISH data by modeling axis-specific measurement errors, showing reliable detection of chromatin loops, TAD boundaries, and A/B compartments.

The paper introduces Droplet Hi-C, a method for single-cell chromatin conformation profiling, and demonstrates its application in analyzing gene regulatory programs and detecting genetic variations in cancer cells.

The paper introduces BNBC, a normalization and batch correction method for Hi-C data, improving cross-sample comparisons and analyses.

Genome-wide association meta-analysis of 130,664 major depression cases and 330,470 controls identifies 44 independent risk loci enriched in cortical neurons, conserved mammalian regions, splicing networks, and antidepressant targets.

HUGIn is a web browser for visualizing Hi-C data from 21 human primary tissues and cell lines to assess chromatin contacts across and specific to tissues or cell lines.