Author

Lei Chang

University of California San Diego

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Biology Disciplines

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Genomics· 2 Cancer Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:clustering· 3 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Organism:human· 3 Assay:scRNA-seq· 2 Assay:spatial transcriptomics· 2

Frequent Co-Authors

Bing ReniD· 4 shared Yang XieiD· 4 shared Brett TayloriD· 3 shared Zhaoning WangiD· 3 shared Clark Chen· 2 shared Frank B. FurnariiD· 2 shared Timothy H. Loe· 2 shared Abhinaba Banerjee· 1 shared

Activity by Year

2024-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersGenomics

Bing RenORCID

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Author profile →

4 papers

Recent·Most cited

Ex vivo glioblastoma migration phenotypes define clinical recurrence and tumor heterogeneity

Jay Hou, Mariah M. McMahon, Andrew Ni, Zhaoning Wang, Brett Taylor, Timothy H. Loe, Yang Xie, Lei Chang, Andrew M. Gardeck, Ziya Gokaslan, SHIRA I. DUNSIGER, Bing Ren, Clark Chen, David J. Odde

This study identifies two migratory phenotypes in glioblastoma cells ex vivo, linking them to clinical recurrence and tumor heterogeneity.

bioRxiv · Sep 2, 2026 · PreprintCancer Biology

A Multimodal Single-Cell Epigenomic and 3D Genome Atlas of the Human Basal Ganglia

Wubin Ding, Amit Klein, Cindy Tatiana Báez-Becerra, Jonathan A. Rink, Anna Bartlett, Ruoxuan Wang, Qiurui Zeng, Rosa Castanon, Joseph R. Nery, Emma Osgood, William S. Owens, Alaina Petrella, Chumo Chen, Andrea Saldana Acerbo, Ariana S. Barcoma, , Joseph R. Ecker

This paper creates a multimodal single-cell atlas of the human basal ganglia, revealing epigenomic and 3D genome features across cell types and linking them to disease-associated genetic risk.

bioRxiv · Jun 23, 2026 · PreprintNeuroscience

Single-molecule spatial genomics reveals the multi-scale organization and plasticity of extrachromosomal DNA in glioblastoma

Brett Taylor, Weixiu Dong, Tula Ann Keal, Zhaoning Wang, Bharath Saravanan, Zane A. Gibbs, Yohei Miyake, Daisuke Kawauchi, Raghavendra Vadla, Abhinaba Banerjee, Omar M. Elkassih, Sahana Kashyap, B. Jones, Kseniya Malukhina, Mahsa Nafisi, , Bogdan Bintu

This study uses single-molecule spatial genomics to show how extrachromosomal DNA is organized and regulated in glioblastoma, linking it to tumor heterogeneity and microenvironmental influences.

bioRxiv · Mar 7, 2026 · PreprintGenomics

Droplet Hi-C for Fast and Scalable Profiling of Chromatin Architecture in Single Cells

Lei Chang, Yang Xie, Brett Taylor, Zhaoning Wang, Jiachen Sun, Tuyet M. Tan, Rafael L. Bejar, Clark C. Chen, Frank B. Furnari, Ming Hu, Bing Ren

The paper introduces Droplet Hi-C, a method for single-cell chromatin conformation profiling, and demonstrates its application in analyzing gene regulatory programs and detecting genetic variations in cancer cells.

bioRxiv · Apr 18, 2024 · PreprintGenomics