Brett Taylor

This study identifies two migratory phenotypes in glioblastoma cells ex vivo, linking them to clinical recurrence and tumor heterogeneity.

This study shows that SETD5 dysfunction in astrocytes increases IL-6, which harms neurons via JAK/STAT signaling, suggesting therapeutic targeting of this pathway for ASD and ID.

This study uses single-molecule spatial genomics to show how extrachromosomal DNA is organized and regulated in glioblastoma, linking it to tumor heterogeneity and microenvironmental influences.

The paper introduces Droplet Hi-C, a method for single-cell chromatin conformation profiling, and demonstrates its application in analyzing gene regulatory programs and detecting genetic variations in cancer cells.

This study identifies the SWS1-SWSAP1-SPIDR complex as a regulator of distinct homologous recombination pathways, with specific roles in inter-homolog HDR and cancer-related genomic instability.