Baptiste Couvy‐Duchesne

Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling

This paper identifies 58 genome-wide significant loci for major anxiety disorders using a large meta-analysis and highlights GABAergic signaling as a potential mechanism.

Utility of polygenic risk scores in diagnostic genetic testing for dilated cardiomyopathy

This study evaluates polygenic risk scores (PRS) in dilated cardiomyopathy (DCM) patients, finding higher PRS in those without monogenic variants and TTN-related DCM, suggesting polygenic contributions.

Dissecting heterogeneity in cortical thickness abnormalities in major depressive disorder: a large-scale ENIGMA MDD normative modelling study

This study uses normative modeling to analyze cortical thickness deviations in MDD patients and healthy controls, finding large overlaps and significant heterogeneity in extreme deviations across individuals.

A Large-Scale ENIGMA Multisite Replication Study of Brain Age in Depression

The paper replicates a brain age gap in depression using a large-scale multisite study, finding a similar effect size to a prior study.

A parsimonious model for mass-univariate vertex-wise analysis

The paper compares GLM and LMM approaches for mass-univariate vertex-wise analysis, showing LMMs reduce false positives and cluster size but increase computation.

Widespread associations between grey matter structure and the human phenome

This paper identifies 58 significant associations between grey matter structure and diverse human phenotypes using large neuroimaging datasets and shows body size factors explain part of these associations.

Brain Aging in Major Depressive Disorder: Results from the ENIGMA Major Depressive Disorder working group

This paper examines brain aging in major depressive disorder (MDD) using a large dataset, finding that MDD patients show increased brain age differences compared to controls.

A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

This study identifies traits associated with polygenic risk for depression using UK Biobank data and finds causal links between depression risk and brain structure, as well as environmental interactions.

The genetic architecture of the human cerebral cortex

The paper identifies genetic loci associated with human cortical structure and finds genetic correlations with neuropsychiatric disorders.

The genetics of the mood disorder spectrum: genome-wide association analyses of over 185,000 cases and 439,000 controls

This study identifies 73 genome-wide significant loci for mood disorders, revealing shared and distinct genetic factors between major depressive disorder and bipolar disorder.

Genetic variation in the Major Histocompatibility Complex and association with depression

This study investigates whether genetic variation in the Major Histocompatibility Complex (MHC) is associated with depression risk, finding no significant associations at a conservative threshold.

Variably methylated regions in the newborn epigenome: environmental, genetic and combined influences

The paper examines how genetic and environmental factors influence DNA methylation at variably methylated regions in neonatal blood, finding that combined effects best explain methylation variability.

Planar cell polarity pathway and development of the human visual cortex

The paper identifies genetic associations with cortical surface area using PCA and GWAS, linking DAAM1 to visual cortex development through mitochondrial pathways and thalamocortical input.

Applying polygenic risk scoring for psychiatric disorders to a large family with Bipolar Disorder and Major Depressive Disorder

The paper applies polygenic risk scoring to a large family with bipolar and depressive disorders to study genetic risk patterns and anticipation.

Higher genetic risk for schizophrenia is associated with living in urban and populated areas

The paper finds a genetic association between schizophrenia risk and urban living, suggesting genetic factors influence migration to densely populated areas.

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

Genome-wide association meta-analysis of 130,664 major depression cases and 330,470 controls identifies 44 independent risk loci enriched in cortical neurons, conserved mammalian regions, splicing networks, and antidepressant targets.