Emery T. Usher

Proteoform plasticity modulates the temperature response in circadian timekeeping

This study investigates how alternative splicing of intrinsically disordered regions in the fungal circadian protein FRQ affects temperature-dependent clock function.

Modes of action and in planta antifungal activity of Olea europaea defensin OefDef1.1-derived peptide variant

This study evaluates a synthetic peptide variant derived from olive defensin OefDef1.1, showing antifungal activity against Botrytis cinerea through membrane permeabilization, vacuolar accumulation, and protein synthesis inhibition.

Direct prediction of intermolecular interactions driven by disordered regions

The paper develops a method to predict intermolecular interactions between intrinsically disordered regions and partner proteins using chemical physics principles.

Molecular insights into the interaction between a disordered protein and a folded RNA

This study characterizes the RNA-binding properties of a disordered protein, SERF, and shows that binding to RNA causes modest global compaction without inducing structural changes in either molecule.

Phosphorylation of disordered proteins tunes local and global intramolecular interactions

This study uses all-atom simulations to model phosphorylation effects on intrinsically disordered proteins, showing agreement with experimental data on conformational changes.

Spatial Organization of Gas Vesicles is Governed by Phase-separable GvpU

The paper identifies GvpU as the protein governing gas vesicle clustering and shows how its phase transition behavior modulates cellular fitness and clustering states.